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	Provedor de dados BABT (2) Autor Gontijo,Cristiano Machado (2) Oliveira,Flávia Márcia (2) Ramaldes,Gilson Andrade (2) Alves,Andrea Catão (1) Cardoso,Valbert Nascimento (1) Cardoso,Valbert do Nascimento (1) Diniz,Simone Odília Fernandes (1) Gusmão,Leandro José (1) Oliveira,Mônica Cristina (1) Ruiz-de-Souza,Valéria (1) Mais... Palavra-chave Absorption (1) Biodistribution (1) Ethanol (1) Immune response (1) Liposomes (1) Mucosal delivery (1) Nanotechnology (1) Oral absorption (1) Proteins (1) Technetium (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2013 (1) 2005 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Biodistribution of free 99mTc-ovalbumin and 99mTc-ovalbumin encapsulated in liposomes BABT Alves,Andrea Catão; Gontijo,Cristiano Machado; Oliveira,Mônica Cristina; Diniz,Simone Odília Fernandes; Oliveira,Flávia Márcia; Cardoso,Valbert Nascimento; Ramaldes,Gilson Andrade. The oral administration of proteic antigens, like ovalbumin, may result in the induction of oral tolerance or immunization. The aim of this work was to label a protein antigen with 99mTechnetium, encapsulate it in liposomes and investigate its absorption and tissue distribution after oral administration in mice. Ovalbumin was labeled with 99mTechnetium and encapsulated in small unilamellar vesicles. 99mTc-OVA encapsulated or not in liposomes was administrated to mice that were sacrificed after different times. The radioactivity was measured in various organs of the animals. Differences concerning the biodistribution of 99mTc-OVA were noticed. The technique may represent alternatives for the induction of immunization or oral tolerance. Tipo: Info:eu-repo/semantics/article Palavras-chave: Liposomes; Oral absorption; Mucosal delivery; Proteins; Nanotechnology. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700035 Ethanol affects the absorption and tissue distribution of orally administered antigens in mice BABT Oliveira,Flávia Márcia; Gusmão,Leandro José; Cardoso,Valbert do Nascimento; Ramaldes,Gilson Andrade; Ruiz-de-Souza,Valéria; Gontijo,Cristiano Machado. The aim of this work was to evaluate the effects of ethanol on the adsorption and tissue distribution of orally administered antigens in mice. Results showed that ethanol reduced the level of anti-ovalbumin IgA antibodies in intestinal fluid for the mice treated orally with a palmitoyl-ovalbumin conjugate. Ethanol was administered intragastrically to mice at 5 g/kg body weight for 14 days (chronic treatment), or 10 g/kg body weight every 7th day up to 14 days (acute treatment). Thereafter, 99m technetium-labeled antigens were administered and lymphoid tissues were collected. Ethanol interfered with the transport of ovalbumin to the liver. Moreover, the transport of palmitoyl-ovalbumin to mesenteric lymph nodes was reduced 6 h after the antigen... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ethanol; Absorption; Biodistribution; Technetium; Immune response. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000400008 Registros recuperados: 2 Primeira ... 1 ... Última

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